Plexus Bio Cleanse Review 2025: Benefits, Side Effects & Results
Introduction
Digestive health is one of the most overlooked aspects of overall wellness. A sluggish digestive system can lead to bloating, irregular bowel movements, low energy levels, and even poor nutrient absorption. In the last few years, detox supplements have gained massive popularity as people search for safe and effective ways to cleanse their systems naturally.
Among the many options available, Plexus® Bio Cleanse® 180 ct stands out as one of the most trusted products. Backed by the well-known Plexus brand, Bio Cleanse is marketed as a gentle detox and digestive support supplement that uses natural ingredients to promote regularity, reduce bloating, and support overall well-being.
In this in-depth review, we’ll look at what makes Plexus Bio Cleanse unique, break down its ingredients, explore the science behind its benefits, and see whether it’s the right choice for those looking to support digestive health.
What is Plexus Bio Cleanse?
Plexus Bio Cleanse is a dietary supplement designed to:
- Support the body’s natural cleansing process
- Promote digestive comfort and regular bowel movements
- Enhance nutrient absorption
- Provide antioxidant support with Vitamin C and citrus bioflavonoids
- Improve overall energy and wellness
Each bottle contains 180 vegetarian capsules, offering a long-lasting supply. The formula is gluten-free, non-GMO, and suitable for both men and women. Unlike harsh detox products that may cause cramping or dehydration, Bio Cleanse is formulated to work gently and consistently.
Ingredient Breakdown: What’s Inside Bio Cleanse?
The strength of any supplement lies in its formulation. Plexus Bio Cleanse combines minerals, antioxidants, and plant compounds to provide balanced digestive support.
1. Vitamin C (150 mg)
- A potent antioxidant that strengthens the immune system.
- Helps combat free radicals and oxidative stress.
- Supports collagen production, which benefits skin, joints, and connective tissues.
- Enhances absorption of iron from plant-based foods.
2. Magnesium Hydroxide (380 mg)
- Acts as a natural osmotic agent, drawing water into the intestines to soften stools and promote regular bowel movements.
- Supports muscle relaxation, including the smooth muscles of the digestive tract.
- Plays a role in over 300 biochemical processes in the body, including energy production.
3. Sodium Bicarbonate (190 mg)
- Commonly known as baking soda, it helps neutralize excess stomach acid.
- Reduces symptoms of bloating, indigestion, and heartburn.
- Supports pH balance in the body, creating a more alkaline environment.
4. Citrus Bioflavonoids (50 mg)
- Natural plant compounds found in oranges, lemons, and other citrus fruits.
- Work synergistically with Vitamin C to boost antioxidant protection.
- Support circulation and capillary health.
- May enhance nutrient absorption.
5. Other Ingredients
- Vegetarian capsule (Hypromellose) – plant-based capsule shell.
- Rice flour – natural filler, used instead of synthetic additives.

How Does Plexus Bio Cleanse Work?
Unlike many detox products that rely on harsh laxatives, Plexus Bio Cleanse focuses on gentle cleansing and digestive comfort. Here’s how it works:
- Magnesium Hydroxide promotes bowel regularity by drawing water into the intestines. This softens stools and supports natural elimination without harsh side effects.
- Sodium Bicarbonate helps with digestion by neutralizing excess acid and reducing bloating, which makes meals easier on the stomach.
- Vitamin C and citrus bioflavonoids provide antioxidant protection, reducing inflammation and supporting immune health.
- Overall, the formula promotes balance in the digestive system while encouraging efficient nutrient absorption, which can lead to higher energy levels.
When used consistently, Bio Cleanse helps create a healthier digestive environment, allowing the body to naturally detoxify and function more efficiently.
Benefits of Plexus Bio Cleanse
- Improves Digestive Regularity
- Helps reduce occasional constipation.
- Promotes smooth and natural bowel movements.
- Reduces Bloating and Discomfort
- Sodium bicarbonate neutralizes stomach acid.
- Supports a balanced pH in the digestive tract.
- Boosts Energy Levels
- Better nutrient absorption = improved natural energy.
- Magnesium plays a key role in energy metabolism.
- Provides Antioxidant Protection
- Vitamin C and bioflavonoids protect against oxidative stress.
- May reduce inflammation in the gut.
- Supports Weight Management (When Paired with TriPlex Regimen)
- Plexus recommends Bio Cleanse as part of the TriPlex System (Bio Cleanse, ProBio 5, and Slim).
- Improves gut health, which indirectly supports weight goals.
Directions for Use
- General Use: Adults take 2 capsules daily with 8 ounces of water.
- As Part of TriPlex Regimen: Take 2 capsules twice daily between meals.
- Drink plenty of water throughout the day for best results.
- Results vary, but consistent use over several weeks typically provides noticeable improvements.
Pros and Cons
Pros
✔ Gentle detox and digestive support
✔ Antioxidant-rich with Vitamin C and bioflavonoids
✔ Gluten-free and vegetarian-friendly
✔ Supports both men and women
✔ Can be combined with other Plexus supplements
✔ Large bottle (180 capsules) provides long-term value
Cons
✘ Results vary from person to person
✘ Not a replacement for a healthy diet
✘ Requires consistent use for maximum benefits
✘ Not evaluated by FDA for disease treatment
Who Should Consider Plexus Bio Cleanse?
- Individuals who struggle with occasional constipation
- People who experience bloating or digestive discomfort
- Those looking for a gentle detox solution
- Men and women seeking overall digestive wellness
- Anyone using the Plexus TriPlex System
Comparison: Plexus Bio Cleanse vs Other Detox Supplements
Unlike many detox supplements that use harsh laxatives or stimulants, Bio Cleanse is designed to be gentle yet effective. While some products focus only on cleansing, Bio Cleanse combines detox support + antioxidants + digestive comfort in one formula.
Many users prefer it because it avoids the side effects often seen with stronger cleansers, such as cramping or dehydration.
Final Verdict: Is Plexus Bio Cleanse Worth It?
Plexus Bio Cleanse is more than just a detox supplement – it’s a comprehensive digestive health product that supports regularity, comfort, and overall wellness. Its blend of Vitamin C, Magnesium, Sodium Bicarbonate, and Citrus Bioflavonoids makes it unique compared to other supplements in the detox market.
If you’re looking for a gentle, daily-use supplement that promotes balance and helps you feel lighter, less bloated, and more energized, Bio Cleanse is a great choice. While it isn’t a miracle pill, consistent use as part of a healthy lifestyle can deliver noticeable long-term benefits.
FAQs
1. How long does it take to see results from Plexus Bio Cleanse?
Some users notice improvements within a few days, while others may need several weeks of consistent use.
2. Can I take Plexus Bio Cleanse every day?
Yes. It is safe for daily use when taken as directed.
3. Does Bio Cleanse help with weight loss?
It is not a direct weight-loss supplement but may support weight management by improving digestion and reducing bloating.
4. Is Plexus Bio Cleanse safe?
Yes, it is made with natural ingredients and is gluten-free. However, individuals with medical conditions should consult a doctor before use.
5. Can I take it without the TriPlex regimen?
Absolutely. Bio Cleanse works both as a standalone supplement and as part of the Plexus TriPlex program.